| Zawody | Termin | Termin typowania | Gospodarz | Gość | Grupa | Wynik | Reguła punktacji |
|---|---|---|---|---|---|---|---|
| IT1 | 02.12.21 18:30 | 02.12.21 18:30 | FC Turyn | FC Empoli | - | 2:2 | 4 - 6 - 8 |
| ENG1 | 02.12.21 21:15 | 02.12.21 21:15 | Manchester United | FC Arsenal | - | 3:2 | 4 - 7 - 9 |
| 1. BL | 03.12.21 20:30 | 03.12.21 20:30 | 1. FC Union Berlin | RB Lipsk | - | 2:1 | 7 - 5 - 4 |
| 1.PL | 04.12.21 12:40 | 04.12.21 12:40 | TS Podbeskidzie | GKS Katowice | - | 1:2 | 3 - 8 - 10 |
| IT1 | 04.12.21 18:00 | 04.12.21 18:00 | AS Roma | Inter Mediolan | - | 0:3 | 6 - 6 - 4 |
| NL1 | 05.12.21 14:30 | 05.12.21 14:30 | AZ Alkmaar | Sparta Rotterdam | - | 3:1 | 3 - 9 - 10 |
| ENG1 | 05.12.21 17:30 | 05.12.21 17:30 | Aston Villa | Leicester City | - | 2:1 | 5 - 5 - 5 |
| EKS | 05.12.21 17:30 | 05.12.21 17:30 | Zagłębie Lubin | Lech Poznań | - | 2:3 | 10 - 9 - 3 |
| ESP1 | 05.12.21 21:00 | 05.12.21 21:00 | Celta Vigo | FC Valencia | - | 1:2 | 5 - 5 - 5 |
| LM | 07.12.21 21:00 | 07.12.21 21:00 | Ajax Amsterdam | Sporting Lizbona | Grupa C | 4:2 | 3 - 7 - 10 |
| LM | 08.12.21 21:00 | 08.12.21 21:00 | FC Bayern Monachium | FC Barcelona | Grupa E | 3:0 | 3 - 10 - 10 |
| LE | 09.12.21 18:45 | 09.12.21 18:45 | SSC Napoli | Leicester City | Grupa C | 3:2 | 3 - 9 - 10 |
| LE | 09.12.21 18:45 | 09.12.21 18:45 | Legia Warszawa | Spartak Moskwa | Grupa C | 0:1 | 5 - 6 - 4 |
| 2.BL | 10.12.21 18:30 | 10.12.21 18:30 | FC Schalke 04 | 1. FC Nürnberg | - | 4:1 | 3 - 8 - 10 |
| EKS | 11.12.21 15:00 | 11.12.21 15:00 | Radomiak | Lech Poznań | - | 2:1 | 8 - 6 - 4 |
| ENG1 | 11.12.21 16:00 | 11.12.21 16:00 | Liverpool FC | Aston Villa | - | 1:0 | 3 - 10 - 10 |
| IT1 | 12.12.21 12:30 | 12.12.21 12:30 | FC Turyn | FC Bologna | - | 2:1 | 4 - 5 - 7 |
| 1. BL | 12.12.21 17:30 | 12.12.21 17:30 | Eintracht Frankfurt | Bayer 04 Leverkusen | - | 5:2 | 7 - 5 - 4 |
| ESP1 | 12.12.21 21:00 | 12.12.21 21:00 | Real Madrid | Atletico Madrid | - | 2:0 | 4 - 6 - 7 |
| 1. BL | 15.12.21 18:30 | 15.12.21 18:30 | Bor. Mönchengladbach | Eintracht Frankfurt | - | 2:3 | 4 - 7 - 5 |
| ENG1 | 15.12.21 20:30 | 15.12.21 20:30 | Brighton and Hove Albion | Wolverhampton Wanderers | - | 0:1 | 4 - 5 - 7 |
| 1. BL | 18.12.21 18:30 | 18.12.21 18:30 | Hertha BSC | Borussia Dortmund | - | 3:2 | 10 - 7 - 3 |
| 2.BL | 18.12.21 20:30 | 18.12.21 20:30 | Hamburger SV | FC Schalke 04 | - | 1:1 | 4 - 5 - 6 |
| EKS | 19.12.21 15:00 | 19.12.21 15:00 | Lech Poznań | Górnik Zabrze | - | 2:1 | 4 - 6 - 10 |
| ESP1 | 19.12.21 18:30 | 19.12.21 18:30 | FC Getafe | CA Osasuna | - | 1:0 | 5 - 5 - 7 |
| IT1 | 19.12.21 20:45 | 19.12.21 20:45 | AC Milan | SSC Napoli | - | 0:1 | 4 - 5 - 6 |
| ESP1 | 21.12.21 21:30 | 21.12.21 21:30 | FC Sevilla | FC Barcelona | - | 1:1 | 6 - 5 - 4 |
| IT1 | 22.12.21 18:30 | 22.12.21 18:30 | AS Roma | Sampdoria Genoa | - | 1:1 | 3 - 10 - 10 |
| ENG1 | 26.12.21 16:00 | 26.12.21 16:00 | Manchester City | Leicester City | - | 6:3 | 3 - 10 - 10 |
| Champ | 30.12.21 20:45 | 30.12.21 20:45 | Nottingham Forest | Huddersfield Town | - | 0:1 | 4 - 6 - 8 |